VoM 2022, about “the latest conquests on viruses of microbes”, is taking place in Guimaraes Portugal.
We are enjoying science and very good octopus!
Can the use of extracellular vesicles and anti-CD38 nanobodies help in the fight against multiple myeloma? This is the question Alain Roussel’s team and its collaborators are trying to answer.
Adeline Goulet received an ANR grant to unravel molecular interactions between the winemaking bacterium Oenococcus oeni, recently-discovered oneophages, and organic compounds of the ecological niche. This is a collaborative project with Claire le Marrec (Université de Bordeaux), Marie-Pierre Chapot-Chartier (INRAE), Douwe van Sinderen and Jennifer Mahony (University Cork College).
Our manuscript entitled “Structure and Topology Prediction of Phage Adhesion Devices Using AlphaFold2: The Case of Two Oenococcus oeni Phages“, is now online and can be accessed via the Microorganisms website.
The sixth symposium of the french PHAGE network takes place in Roscoff (Brittany). We are enjoying science and delicious “crêpes”!
Isabelle Imbert received the insignia of Knight of the French Légion d’Honneur from Dr Pierre Petitbon, President of the Orne Society of Members of the Legion of Honour, accompanied by his counterpart for Marseille, Guy Dabadie. This award follows her long-time work on SARS-CoV.
Our collaborative paper “Combining DEVS and semantic technologies for modeling the SARS-CoV-2 replication machinery” has received the Best Paper Award of the Annual Modeling and Simulation Conference 2021.
We are pleased to welcome Pauline Perné, who joined the team as a Master student (ENSCBP Engineer School, Bordeaux, FR) to work with Adeline Goulet. Welcome Pauline !
whose one (7BNP) highlighting a domain-swapping
Trinh, T.T.N., Gaubert, A., Melani, P., Cambillau, C., Roussel, A. & Leone, P. (2021), Acta Cryst. F77. https://doi.org/10.1107/S2053230X21005185
We are pleased to welcome Emilie Cenraud, who joined the team as a Master student (ISBS Engineer School, Paris Est Créteil University, FR) to work with Adeline Goulet. Welcome Emilie !
We are pleased to welcome Katerina Filopoulou, who joined the team as a Master student (Master of Structural Biology and Genomics, Aix-Marseille University, FR) to work with Adeline Goulet. Welcome Katerina !
Listen to the interview of Alain Roussel to understand everything about the new smartphone diagnostic technology developed by our team and the IEMN laboratory of Lille. (French interview)
The objective of this proposal aims at deciphering the mechanism of action of the recently discovered type IX secretion system (T9SS). The T9SS is responsible for Porphyromonas gingivalis pathogenesis through secretion of virulence factors, and for Flavobacterium johnsoniae motility through secretion of adhesins. Among the 18 identified proteins that are involved in T9SS function, the K-L-M-N proteins are supposed to form the core complex. We propose that the outer membrane ring-shaped K-N complex serves as an interaction platform to recruit the inner membrane L-M complex, and that the L-M complex is a novel rotary motor driven by proton motive force. In this project, we will solve the structures of the isolated soluble domains of L and N proteins, and of the L-M and K-L-M-N membrane complexes from the two bacterial models, by X-ray crystallography and cryo-EM. The function of the L-M complex, and notably its role as a rotary motor, will be addressed by in vivo approaches.
We are pleased to welcome Laura Schmitt, who joined the team as engineer to work with Adeline Goulet. Welcome Laura !
Vincent Delauzun’s thesis defence, Extracellular vesicles: an ideal tool for the study of membrane proteins, will be broadcast on the zoom platform.
ID de réunion : 942 7107 8490
Code secret : 1234
Our manuscript entitled « Wine phenolic compounds differently affect the host-killing activity of two lytic bacteriophages infecting the lactic acid bacterium Oenococcus oeni”, is now online and can be accessed via the Viruses website.