ABOUT
Host-pathogen interactions
Understanding host-pathogen interactions is at the heart of the fight against pathogens involved in infectious diseases (viruses, bacteria).
RESEARCH GROUPS
Link to: Alain Roussel
Alain Roussel’s group
The studies we conduct focus on one hand on factors of pathogenicity of bacteria and on the other hand on means of response of host organisms. Our projects can be grouped in 2 disciplines which are immunology and microbiology.
Link to: Adeline Goulet
Adeline Goulet’s group
Bacteriophages (phages) are the most abundant biological entities on Earth. Yet, these sophisticated bacteria-killing nanomachines remain poorly understood.
What has made them so successful?
Link to: Isabelle Imbert
Isabelle Imbert’s group
RNA viruses are responsible for all emerging infectious diseases (Ebola, Coronaviruses…). Combining multidisciplinary approaches such as biochemistry, enzymology, structural biology and artificial intelligence methods, we aim to dissect fascinating RNA virus replication machineries.
Link to: Philippe Leone
Philippe Leone’s group
Our objective is to solve the structures of the isolated soluble domains of L and N proteins, and of the L-M and K-L-M-N membrane complexes of T9SS from two bacterial models, by X-ray crystallography and cryo-EM.
JOIN US
We are always looking for talented and motivated research trainees, Ph.D students or post-doctoral fellows so please feel free to contact us.
LATEST PUBLICATIONS
Structure Prediction and Analysis of Hepatitis E Virus Non-Structural Proteins from the Replication and Transcription Machinery by AlphaFold2 (2022)
Goulet A, Cambillau C, Roussel A, Imbert I. Viruses Jul 14; 14(7):1537
Replication of the coronavirus genome: A paradox among positive-strand RNA viruses (2022)
Grellet E, L'Hôte I, Goulet A, Imbert I. J Biol Chem May; 298(5):101923.
Structure and topology predictions of phage adhesion devices using AlphaFold2: the case of two Oenococcus oeni phages (2021)
Goulet A and Cambillau C
Goulet A, Cambillau C, Roussel A, Imbert I. Viruses Jul 14; 14(7):1537
Replication of the coronavirus genome: A paradox among positive-strand RNA viruses (2022)
Grellet E, L'Hôte I, Goulet A, Imbert I. J Biol Chem May; 298(5):101923.
Structure and topology predictions of phage adhesion devices using AlphaFold2: the case of two Oenococcus oeni phages (2021)
Goulet A and Cambillau C
OntoRepliCoV: an ontology-based approach for modeling the SARS-CoV-2 replication process (2021)
Laddada W, Soualmia LF, Zanni-Merk C, Ayadi A, Frydman C, L’Hote I, Imbert I. Procedia Comput Sci.
Wine phenolic compounds differently affect the host-killing activity of two lytic bacteriophages infecting the lactic acid bacterium Oenococcus oeni (2020)
Philippe C, Chaïb A, Jaomanjaka F, Cluzet S, Lagarde Am Ballestra P, Decendit A, Pétrel M, Claisse O, Goulet A, Cambillau C, Le Marrec C
Structural insights into lactococcal siphophage p2 baseplate activation mechanism (2020)
Spinelli S, Tremblay D, Moineau S, Cambillau C, Goulet A
Laddada W, Soualmia LF, Zanni-Merk C, Ayadi A, Frydman C, L’Hote I, Imbert I. Procedia Comput Sci.
Wine phenolic compounds differently affect the host-killing activity of two lytic bacteriophages infecting the lactic acid bacterium Oenococcus oeni (2020)
Philippe C, Chaïb A, Jaomanjaka F, Cluzet S, Lagarde Am Ballestra P, Decendit A, Pétrel M, Claisse O, Goulet A, Cambillau C, Le Marrec C
Structural insights into lactococcal siphophage p2 baseplate activation mechanism (2020)
Spinelli S, Tremblay D, Moineau S, Cambillau C, Goulet A
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LISM-Laboratoire d’Ingénierie des Systèmes Macromoléculaires
CNRS Campus Joseph Aiguier
31 chemin Joseph Aiguier
13402 Marseille CEDEX 20