ABOUT
Host-pathogen interactions
Understanding host-pathogen interactions is at the heart of the fight against pathogens involved in infectious diseases (viruses, bacteria).
RESEARCH GROUPS
Alain Roussel’s group
The studies we conduct focus on one hand on factors of pathogenicity of bacteria and on the other hand on means of response of host organisms. Our projects can be grouped in 2 disciplines which are immunology and microbiology.
Adeline Goulet’s group
Bacteriophages (phages) are the most abundant biological entities on Earth. Yet, these sophisticated bacteria-killing nanomachines remain poorly understood.
What has made them so successful?
Isabelle Imbert’s group
RNA viruses are responsible for all emerging infectious diseases (Ebola, Coronaviruses…). Combining multidisciplinary approaches such as biochemistry, enzymology, structural biology and artificial intelligence methods, we aim to dissect fascinating RNA virus replication machineries.
Philippe Leone’s group
Our objective is to solve the structures of the isolated soluble domains of L and N proteins, and of the L-M and K-L-M-N membrane complexes of T9SS from two bacterial models, by X-ray crystallography and cryo-EM.
JOIN US
We are always looking for talented and motivated research trainees, Ph.D students or post-doctoral fellows so please feel free to contact us.
LATEST PUBLICATIONS
Goulet A and Cambillau C
OntoRepliCoV: an ontology-based approach for modeling the SARS-CoV-2 replication process (2021)
Laddada W, Soualmia LF, Zanni-Merk C, Ayadi A, Frydman C, L’Hote I, Imbert I.
Wine phenolic compounds differently affect the host-killing activity of two lytic bacteriophages infecting the lactic acid bacterium Oenococcus oeni (2020)
Philippe C, Chaïb A, Jaomanjaka F, Cluzet S, Lagarde Am Ballestra P, Decendit A, Pétrel M, Claisse O, Goulet A, Cambillau C, Le Marrec C
Spinelli S, Tremblay D, Moineau S, Cambillau C, Goulet A
Conserved and diverse traits of adhesion devices from Siphoviridae recognizing proteinaceous or saccharidic receptors (2020)
Goulet A, Spinelli S, Mahony J, Cambillau C
Revisiting the host adhesion determinants of Streptococcus thermophilus siphophages (2020)
Lavelle K, Goulet A, McDonnell B, Spinelli S, van Sinderen D, Mahony J, Cambillau C